China (Mainland)
Top Quality CAS 54-85-3 Isonicotinic Acid Hydrazide / Isoniazid Powder CAS NO.54-85-3
- FOB Price: USD: 150.00-200.00 /Kilogram Get Latest Price
- Min.Order: 1 Gram
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- Available Specifications:
Pharmaceutical Grade(1-10)KilogramPharmaceutical Grade(11-100)Kilogram
- Product Details
Keywords
- isonicotinic acid hydrazide
- 54-85-3
- isoniazid
Quick Details
- ProName: Top Quality CAS 54-85-3 Isonicotinic A...
- CasNo: 54-85-3
- Molecular Formula: C6H7N3O
- Appearance: White crystal
- Application: Mainly use in pharmaceutical intermedi...
- DeliveryTime: Abiut 10 days
- PackAge: Aluminum foil bag,fluorinated bottles,...
- Port: Shenzhen port
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 99%
- Storage: Store in cool & dry place. Keep away f...
- Transportation: 1) Door to Door Service by DHL/FEDEX/E...
- LimitNum: 1 Gram
- Moisture Content: <0.1%
- Impurity: <0.1%
Superiority
1) Provide costomers with "one-stop"packaging service,from research,development,production,export and so on.
2) We have our own R&D and production base,equipped with advanced production equipment and precision testing the Unitef States Pharmacopoeia(USP),the Britis Pharmacopoeia(EP) and other international advanced standards.All products are through the KOSGER,HALAL certification,the ISO quality management system certification and the HACCP certification.
3) More than 12 years of export experience.
4)Competitive price in China market.
Details
|
Product Name |
Isoniazid |
|
Synonyms |
isonicotinic acid hydrazide |
|
CAS |
54-85-3 |
|
Molecular Formula |
C6H7N3O |
|
Molecular Weight |
137.14 |
|
Density |
1.6910g/cm3 |
|
Melting Point |
171-173°C |
|
Boiling Point |
251.97 |
|
Flash Point |
>250°C |
|
Storage |
Refrigerator |
|
Water Solubility |
14 g/100 mL (25 ºC) |
|
Appearance |
White crystalline powder |
Description:
Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.
Antituberculosis It inhibits and kills Mycobacterium tuberculosis. Its biomembrane permeability is good. Because of its good curative effect, low toxicity, low cost, and convenience for oral administration, it is listed as the first choice antituberculosis drug.
Antidepressant Isoniazid is also the first antidepressant drug, but it exits the market because of its hepatotoxicity.
Antibacterial Isoniazid is highly selective for Mycobacterium tuberculosis, strong antibacterial activity, bacteria have bactericidal effect
Uses:
1.antibacterial, tuberculostatic
2.For the treatment of all forms of tuberculosis in which organisms are susceptible.
3.Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.
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